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CAS No.: 112960-16-4

PD128907 盐酸盐 Catalog No. CSN13887

Synonyms: PD128907 Hydrochloride

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

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生物活性

实验方案

技术信息

生物活性

描述(+)-PD 128907 hydrochloride (HCl) is a selective dopamine D2/D3 receptor agonist, with Kis of 1.7, 0.84 nM for human and rat D3 receptors, 179, 770 n M for human and rat D3 receptors, respectively^[3]. (+)-PD 128907 significantly decreases dialysate DA levels in D3 knock out mice. The IC25 values are 61 nM and 1327 nM, respectively, for wild type and D3 knock out mice. Post-hoc analysis shows that all doses tested (0.03, 0.1 and 0.3 mg/kg) significantly inhibit dialysate DA. The IC25 values are 0.05 and 0.44 mg/kg for wild type and knock out mice, respectively, indicating that systemically administered (+)-PD 128907 is 9 times more potent in decreasing dialysate DA in the ventral striatum of wild type as compared to D3 knock out mice. Doses of 1 mg/kg or higher of (+)-PD 128907 markedly inhibits dialysate DA in both wild type and D3 knock out mice^[4]. Low doses of (+)-PD 128907 reduced spontaneous locomotor activity in the rat (ED50 = 13 +/- 3 micrograms/kg, s.c.) a response which was comparable with the non-selective D2,3 receptor agonist apomorphine (ED50 = 13 +/- 1.6 micrograms/kg, s.c.). In addition (+)-PD 128907 impaired prepulse inhibition of the acoustic startle response, with significant effects observed at doses of 30 mg/kg when appropriate prepulse intensities were used^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4993 mL
- 17.4966 mL
- 34.9932 mL
- 5 mM
- 0.6999 mL
- 3.4993 mL
- 6.9986 mL
- 10 mM
- 0.3499 mL
- 1.7497 mL
- 3.4993 mL

技术信息

CAS号

112960-16-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H20ClNO3

运输

蓝冰

分子量

285.77

别名

PD128907 Hydrochloride

溶解度

DMSO	12.0 mg/mL (42.0 mM)
Water	50.0 mg/mL (175.0 mM) warming
Ethanol	Insoluble

动物实验配方

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